Cell Senescence Entries for SMURF2

Cell Types
Foreskin fibroblast, Lung fibroblast, Skin fibroblast
Cell Lines
BJ, WI-38, WS1
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Zhang et al. (2005) Smurf2 up-regulation activates telomere-dependent senescence. Genes Dev 18(24)3028-40 (PubMed)

SMURF2 Gene Information

HGNC symbol
SMURF2 
Aliases
 
Common name
SMAD specific E3 ubiquitin protein ligase 2 
Entrez Id
64750
Description

SMURF2 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:45892; negative regulation of transcription, DNA-templated
GO:6511; ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:30514; negative regulation of BMP signaling pathway
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:45732; positive regulation of protein catabolic process
GO:30579; ubiquitin-dependent SMAD protein catabolic process
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:17015; regulation of transforming growth factor beta receptor signaling pathway
GO:122; negative regulation of transcription by RNA polymerase II
And 4 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:16020; membrane
GO:5886; plasma membrane
GO:45121; membrane raft
GO:5654; nucleoplasm
GO:5829; cytosol
GO:151; ubiquitin ligase complex
Function: GO:16740; transferase activity
GO:4842; ubiquitin-protein transferase activity
GO:5515; protein binding
GO:61630; ubiquitin protein ligase activity
GO:42802; identical protein binding
GO:46332; SMAD binding
Show all GO terms

Homologs of SMURF2 in Model Organisms

Danio rerio
smurf2
Mus musculus
Smurf2
Rattus norvegicus
Smurf2

In other databases

CellAge gene expression
  • This gene is present as SMURF2

External links

OMIM
605532
Ensembl
ENSG00000108854
Entrez Gene
64750
UniGene
515011
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMURF2
GeneCards
SMURF2