Cell Senescence Entries for SOCS1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Induces
Primary Reference
Calabrese et al. (2010) SOCS1 links cytokine signaling to p53 and senescence. Mol Cell 36(5)754-67 (PubMed)

SOCS1 Gene Information

HGNC symbol
SOCS1 
Aliases
Cish1; JAB; SOCS-1; SSI-1; TIP3 
Common name
suppressor of cytokine signaling 1 
Entrez Id
8651
Description
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].

SOCS1 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:35556; intracellular signal transduction
GO:9968; negative regulation of signal transduction
GO:43086; negative regulation of catalytic activity
GO:40008; regulation of growth
GO:43551; regulation of phosphatidylinositol 3-kinase activity
GO:19221; cytokine-mediated signaling pathway
GO:46426; negative regulation of receptor signaling pathway via JAK-STAT
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:42532; negative regulation of tyrosine phosphorylation of STAT protein
GO:1932; regulation of protein phosphorylation
And 13 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:31410; cytoplasmic vesicle
GO:5654; nucleoplasm
GO:36464; cytoplasmic ribonucleoprotein granule
GO:5942; phosphatidylinositol 3-kinase complex
GO:5829; cytosol
Function: GO:5515; protein binding
GO:46935; 1-phosphatidylinositol-3-kinase regulator activity
GO:19901; protein kinase binding
GO:5159; insulin-like growth factor receptor binding
GO:4860; protein kinase inhibitor activity
GO:19210; kinase inhibitor activity
Show all GO terms

Homologs of SOCS1 in Model Organisms

Caenorhabditis elegans
CELE_F39B2.5
Danio rerio
socs1a
Drosophila melanogaster
Socs44A
Mus musculus
Socs1
Rattus norvegicus
Socs1

In other databases

LongevityMap
  • This gene is present as SOCS1

External links

OMIM
603597
Ensembl
ENSG00000185338
Entrez Gene
8651
UniGene
50640
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SOCS1
GeneCards
SOCS1