Cell Senescence Entries for SOX5

Cell Types
Glioma
Cell Lines
U-1242MG, U-178MG, U-251MG, U-343MG, U-343MGa
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Tchougounova et al. (2009) Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence. Oncogene 28(12)1537-48 (PubMed)

SOX5 Gene Information

HGNC symbol
SOX5 
Aliases
L-SOX5; MGC35153 
Common name
SRY-box transcription factor 5 
Entrez Id
6660
Description
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

SOX5 Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:51216; cartilage development
GO:6357; regulation of transcription by RNA polymerase II
GO:32332; positive regulation of chondrocyte differentiation
GO:6366; transcription by RNA polymerase II
GO:71560; cellular response to transforming growth factor beta stimulus
GO:2062; chondrocyte differentiation
GO:45165; cell fate commitment
GO:61036; positive regulation of cartilage development
GO:1502; cartilage condensation
GO:55059; asymmetric neuroblast division
GO:2000741; positive regulation of mesenchymal stem cell differentiation
Cellular component: GO:5634; nucleus
GO:785; chromatin
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:3700; DNA-binding transcription factor activity
Hide GO terms

Homologs of SOX5 in Model Organisms

Danio rerio
sox5
Mus musculus
Sox5

In other databases

LongevityMap
  • This gene is present as SOX5

External links

OMIM
604975
Ensembl
ENSG00000134532
Entrez Gene
6660
UniGene
657542
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SOX5
GeneCards
SOX5