Cell Senescence Entries for SPAG9

Cell Types
Breast cancer
Cell Lines
MDA-MB-231
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Jagadish et al. (2017) Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. Tumour Biol 37(10)13101-13110 (PubMed)

SPAG9 Gene Information

HGNC symbol
SPAG9 
Aliases
CT89; FLJ13450; FLJ14006; FLJ26141; FLJ34602; HLC4; HSS; JIP-4; JIP4; JLP; KIAA0516; MGC117291; MGC14967; MGC74461; PHET; PIG6; SYD1 
Common name
sperm associated antigen 9 
Entrez Id
9043
Description
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011].

SPAG9 Ontologies

Gene Ontology
Process: GO:16192; vesicle-mediated transport
GO:30335; positive regulation of cell migration
GO:42147; retrograde transport, endosome to Golgi
GO:1933; negative regulation of protein phosphorylation
GO:32418; lysosome localization
GO:43410; positive regulation of MAPK cascade
GO:45665; negative regulation of neuron differentiation
GO:45666; positive regulation of neuron differentiation
GO:51146; striated muscle cell differentiation
GO:1903860; negative regulation of dendrite extension
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:31410; cytoplasmic vesicle
GO:5829; cytosol
GO:5765; lysosomal membrane
GO:5764; lysosome
GO:48471; perinuclear region of cytoplasm
GO:34451; centriolar satellite
GO:1669; acrosomal vesicle
GO:70062; extracellular exosome
GO:16021; integral component of membrane
And 1 more GO terms
Function: GO:5515; protein binding
GO:5078; MAP-kinase scaffold activity
GO:19894; kinesin binding
GO:30159; signaling receptor complex adaptor activity
GO:8432; JUN kinase binding
GO:42802; identical protein binding
Show all GO terms

Homologs of SPAG9 in Model Organisms

Caenorhabditis elegans
unc-16
Danio rerio
spag9a
Mus musculus
Spag9
Rattus norvegicus
Spag9

External links

OMIM
605430
Ensembl
ENSG00000008294
Entrez Gene
9043
UniGene
463439
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SPAG9
GeneCards
SPAG9