Cell Senescence Entries for SPARC

Cell Types
Colon cancer
Cell Lines
MIP-101
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Chan et al. (2010) Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53. Carcinogenesis 31(5)812-9 (PubMed)

SPARC Gene Information

HGNC symbol
SPARC 
Aliases
BM-40; ON; ONT 
Common name
secreted protein acidic and cysteine rich 
Entrez Id
6678
Description
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015].

SPARC Ontologies

Gene Ontology
Process: GO:22604; regulation of cell morphogenesis
GO:16525; negative regulation of angiogenesis
GO:48856; anatomical structure development
GO:1937; negative regulation of endothelial cell proliferation
GO:10595; positive regulation of endothelial cell migration
Cellular component: GO:5737; cytoplasm
GO:5615; extracellular space
GO:43231; intracellular membrane-bounded organelle
GO:5576; extracellular region
GO:9986; cell surface
GO:5604; basement membrane
GO:62023; collagen-containing extracellular matrix
GO:5886; plasma membrane
GO:16363; nuclear matrix
GO:31091; platelet alpha granule
GO:31093; platelet alpha granule lumen
And 4 more GO terms
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:5509; calcium ion binding
GO:5518; collagen binding
GO:50840; extracellular matrix binding
GO:5201; extracellular matrix structural constituent
Show all GO terms

Homologs of SPARC in Model Organisms

Caenorhabditis elegans
ost-1
Danio rerio
sparc
Drosophila melanogaster
BM-40-SPARC
Mus musculus
Sparc
Rattus norvegicus
Sparc

In other databases

CellAge gene expression
  • This gene is present as SPARC

External links

OMIM
182120
Ensembl
ENSG00000113140
Entrez Gene
6678
UniGene
111779
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SPARC
GeneCards
SPARC