Cell Senescence Entries for SRC

Cell Types
Fibrosarcoma
Cell Lines
HT1080
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Vigneron et al. (2005) Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1. Cancer Res 65(19)8927-35 (PubMed)

SRC Gene Information

HGNC symbol
SRC 
Aliases
ASV; c-src; SRC1 
Common name
SRC proto-oncogene, non-receptor tyrosine kinase 
Entrez Id
6714
Description
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

SRC Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:7155; cell adhesion
GO:2376; immune system process
GO:7229; integrin-mediated signaling pathway
GO:45087; innate immune response
GO:46777; protein autophosphorylation
GO:51897; positive regulation of protein kinase B signaling
GO:30154; cell differentiation
And 118 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5770; late endosome
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
And 15 more GO terms
Function: GO:5524; ATP binding
GO:5515; protein binding
GO:4672; protein kinase activity
GO:4713; protein tyrosine kinase activity
GO:166; nucleotide binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:5102; signaling receptor binding
GO:19899; enzyme binding
And 24 more GO terms
Show all GO terms

Homologs of SRC in Model Organisms

Danio rerio
src
Mus musculus
Src
Rattus norvegicus
Src

External links

OMIM
190090
Ensembl
ENSG00000197122
Entrez Gene
6714
UniGene
195659
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SRC
GeneCards
SRC