Cell Senescence Entries for SRSF2

Cell Types
Aortic endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Latorre et al. (2019) Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2. Aging (Albany NY) 10(7)1666-1681 (PubMed)

SRSF2 Gene Information

HGNC symbol
SRSF2 
Aliases
PR264; SC-35; SC35; SFRS2; SFRS2A 
Common name
serine and arginine rich splicing factor 2 
Entrez Id
6427
Description
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010].

SRSF2 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:381; regulation of alternative mRNA splicing, via spliceosome
GO:45892; negative regulation of transcription, DNA-templated
GO:398; mRNA splicing, via spliceosome
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5737; cytoplasm
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5515; protein binding
GO:3714; transcription corepressor activity
Show all GO terms

Homologs of SRSF2 in Model Organisms

Danio rerio
srsf2a
Mus musculus
Srsf2
Rattus norvegicus
Srsf2

External links

OMIM
600813
Ensembl
ENSG00000161547
Entrez Gene
6427
UniGene
584801
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SRSF2
GeneCards
SRSF2