Cell Senescence Entries for STAG2

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Daniloski et al. (2017) Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells. Cancer Res 77(20)5530-5542 (PubMed)

STAG2 Gene Information

HGNC symbol
STAG2 
Aliases
SA-2; SA2; SCC3B 
Common name
stromal antigen 2 
Entrez Id
10735
Description
The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].

STAG2 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:51321; meiotic cell cycle
GO:7059; chromosome segregation
GO:90307; mitotic spindle assembly
GO:7062; sister chromatid cohesion
GO:34089; establishment of meiotic sister chromatid cohesion
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:1650; fibrillar center
GO:785; chromatin
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:16363; nuclear matrix
GO:5829; cytosol
GO:97431; mitotic spindle pole
And 3 more GO terms
Function: GO:5515; protein binding
GO:3682; chromatin binding
Show all GO terms

Homologs of STAG2 in Model Organisms

Danio rerio
stag2b
Mus musculus
Stag2
Rattus norvegicus
Stag2

External links

OMIM
300826
Ensembl
ENSG00000101972
Entrez Gene
10735
UniGene
624663
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STAG2
GeneCards
STAG2