Cell Senescence Entries for STAT1

Cell Types
Glomerular mesangial cell
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Jiao et al. (2012) Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence. Can J Physiol Pharmacol 90(1)89-98 (PubMed)

STAT1 Gene Information

HGNC symbol
STAT1 
Aliases
ISGF-3; STAT91 
Common name
signal transducer and activator of transcription 1 
Entrez Id
6772
Description
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020].

STAT1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:19221; cytokine-mediated signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:51607; defense response to virus
GO:8015; blood circulation
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:60333; interferon-gamma-mediated signaling pathway
GO:60337; type I interferon signaling pathway
And 37 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:32991; protein-containing complex
GO:30425; dendrite
GO:30424; axon
GO:48471; perinuclear region of cytoplasm
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
And 2 more GO terms
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5164; tumor necrosis factor receptor binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:45296; cadherin binding
And 13 more GO terms
Show all GO terms

Homologs of STAT1 in Model Organisms

Caenorhabditis elegans
sta-1
Danio rerio
stat1a
Mus musculus
Stat1
Rattus norvegicus
Stat1

In other databases

CellAge gene expression
  • This gene is present as STAT1

External links

OMIM
600555
Ensembl
ENSG00000115415
Entrez Gene
6772
UniGene
743244
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STAT1
GeneCards
STAT1