Cell Senescence Entries for STAT6

Cell Types
Kidney cancer
Cell Lines
Caki-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Kim et al. (2013) Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK. J Biol Chem 288(40)28743-54 (PubMed)

STAT6 Gene Information

HGNC symbol
STAT6 
Aliases
D12S1644; IL-4-STAT 
Common name
signal transducer and activator of transcription 6 
Entrez Id
6778
Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

STAT6 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:6357; regulation of transcription by RNA polymerase II
GO:6952; defense response
GO:19221; cytokine-mediated signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:42127; regulation of cell population proliferation
GO:120162; positive regulation of cold-induced thermogenesis
GO:7259; receptor signaling pathway via JAK-STAT
GO:43434; response to peptide hormone
GO:60397; growth hormone receptor signaling pathway via JAK-STAT
And 12 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:45121; membrane raft
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:19903; protein phosphatase binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of STAT6 in Model Organisms

Drosophila melanogaster
Stat92E
Mus musculus
Stat6
Rattus norvegicus
Stat6

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Stat92E

External links

OMIM
601512
Ensembl
ENSG00000166888
Entrez Gene
6778
UniGene
524518
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STAT6
GeneCards
STAT6