Cell Senescence Entries for STIM1

Cell Types
Prostate cancer
Cell Lines
DU145, PC-3
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Unclear
Primary Reference
Xu et al. (2016) STIM1 accelerates cell senescence in a remodeled microenvironment but enhances the epithelial-to-mesenchymal transition in prostate cancer. Sci Rep 5(2)11754 (PubMed)

STIM1 Gene Information

HGNC symbol
STIM1 
Aliases
D11S4896E; GOK 
Common name
stromal interaction molecule 1 
Entrez Id
6786
Description
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].

STIM1 Ontologies

Gene Ontology
Process: GO:32237; activation of store-operated calcium channel activity
GO:51924; regulation of calcium ion transport
GO:6811; ion transport
GO:6816; calcium ion transport
GO:45766; positive regulation of angiogenesis
GO:6874; cellular calcium ion homeostasis
GO:70166; enamel mineralization
GO:2115; store-operated calcium entry
GO:5513; detection of calcium ion
GO:45762; positive regulation of adenylate cyclase activity
GO:2001256; regulation of store-operated calcium entry
And 1 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:43229; intracellular organelle
GO:30176; integral component of endoplasmic reticulum membrane
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5874; microtubule
GO:16529; sarcoplasmic reticulum
And 5 more GO terms
Function: GO:46872; metal ion binding
GO:5246; calcium channel regulator activity
GO:5515; protein binding
GO:5509; calcium ion binding
GO:42802; identical protein binding
GO:2020; protease binding
GO:51010; microtubule plus-end binding
Show all GO terms

Homologs of STIM1 in Model Organisms

Danio rerio
stim1b
Mus musculus
Stim1
Rattus norvegicus
Stim1

External links

OMIM
605921
Ensembl
ENSG00000167323
Entrez Gene
6786
UniGene
657794
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STIM1
GeneCards
STIM1