Cell Senescence Entries for SUV39H1

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Mutation
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Mendelsohn et al. (2016) Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging. Rejuvenation Res 18(4)371-5 (PubMed)

SUV39H1 Gene Information

HGNC symbol
SUV39H1 
Aliases
KMT1A; SUV39H 
Common name
SUV39H1 histone lysine methyltransferase 
Entrez Id
6839
Description
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

SUV39H1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:32259; methylation
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:30154; cell differentiation
GO:48511; rhythmic process
GO:6364; rRNA processing
GO:34968; histone lysine methylation
GO:42754; negative regulation of circadian rhythm
GO:6974; cellular response to DNA damage stimulus
GO:183; rDNA heterochromatin assembly
And 11 more GO terms
Cellular component: GO:5634; nucleus
GO:5694; chromosome
GO:5654; nucleoplasm
GO:775; chromosome, centromeric region
GO:792; heterochromatin
GO:794; condensed nuclear chromosome
GO:5730; nucleolus
GO:61773; eNoSc complex
GO:5677; chromatin silencing complex
GO:33553; rDNA heterochromatin
GO:5652; nuclear lamina
And 1 more GO terms
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:5515; protein binding
GO:18024; histone-lysine N-methyltransferase activity
GO:976; transcription cis-regulatory region binding
GO:8757; S-adenosylmethionine-dependent methyltransferase activity
GO:42054; histone methyltransferase activity
GO:47485; protein N-terminus binding
GO:3682; chromatin binding
And 2 more GO terms
Show all GO terms

Homologs of SUV39H1 in Model Organisms

Danio rerio
suv39h1b
Drosophila melanogaster
Su(var)3-9
Mus musculus
Suv39h1
Rattus norvegicus
Suv39h1

External links

OMIM
300254
Ensembl
ENSG00000101945
Entrez Gene
6839
UniGene
522639
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SUV39H1
GeneCards
SUV39H1