Cell Senescence Entries for SUZ12

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Inhibits
Primary Reference
Martin et al. (2013) Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation. EMBO J 32(7)982-95 (PubMed)

SUZ12 Gene Information

HGNC symbol
SUZ12 
Aliases
CHET9; JJAZ1; KIAA0160 
Common name
SUZ12 polycomb repressive complex 2 subunit 
Entrez Id
23512
Description
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009].

SUZ12 Ontologies

Gene Ontology
Process: GO:50790; regulation of catalytic activity
GO:6325; chromatin organization
GO:45596; negative regulation of cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:8284; positive regulation of cell population proliferation
GO:9048; dosage compensation by inactivation of X chromosome
GO:16571; histone methylation
GO:16574; histone ubiquitination
GO:48709; oligodendrocyte differentiation
GO:6807; nitrogen compound metabolic process
GO:44238; primary metabolic process
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:16604; nuclear body
GO:35098; ESC/E(Z) complex
GO:1739; sex chromatin
GO:5677; chromatin silencing complex
GO:32993; protein-DNA complex
Function: GO:46872; metal ion binding
GO:5515; protein binding
GO:35064; methylated histone binding
GO:31490; chromatin DNA binding
GO:1222; transcription corepressor binding
GO:8047; enzyme activator activity
GO:42054; histone methyltransferase activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:3723; RNA binding
GO:43565; sequence-specific DNA binding
And 2 more GO terms
Show all GO terms

Homologs of SUZ12 in Model Organisms

Danio rerio
suz12b
Drosophila melanogaster
Su(z)12
Mus musculus
Suz12
Rattus norvegicus
Suz12

External links

OMIM
606245
Ensembl
ENSG00000178691
Entrez Gene
23512
UniGene
462732
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SUZ12
GeneCards
SUZ12