Cell Senescence Entries for TBPL1

Cell Types
Colon cancer
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Maeda et al. (2017) TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation. J Biol Chem 292(8)3201-3212 (PubMed)

TBPL1 Gene Information

HGNC symbol
TBPL1 
Aliases
STUD; TLF; TLP; TRF2 
Common name
TATA-box binding protein like 1 
Entrez Id
9519
Description
This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011].

TBPL1 Ontologies

Gene Ontology
Process: GO:6352; DNA-templated transcription, initiation
GO:6366; transcription by RNA polymerase II
GO:1675; acrosome assembly
GO:6235; dTTP biosynthetic process
GO:7283; spermatogenesis
GO:7289; spermatid nucleus differentiation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5672; transcription factor TFIIA complex
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:16251; RNA polymerase II general transcription initiation factor activity
GO:140223; general transcription initiation factor activity
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
Show all GO terms

Homologs of TBPL1 in Model Organisms

Danio rerio
tbpl1
Mus musculus
Tbpl1
Rattus norvegicus
Tbpl1

External links

OMIM
605521
Ensembl
ENSG00000028839
Entrez Gene
9519
UniGene
486507
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TBPL1
GeneCards
TBPL1