Cell Senescence Entries for TEAD1

Cell Types
Gastric cancer
Cell Lines
MGC-803, MKN28, SGC-7901
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Zhou et al. (2017) TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. Oncogene 36(47)6518-6530 (PubMed)

TEAD1 Gene Information

HGNC symbol
TEAD1 
Aliases
AA; TCF13; TEF-1 
Common name
TEA domain transcription factor 1 
Entrez Id
7003
Description
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010].

TEAD1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:35329; hippo signaling
GO:6357; regulation of transcription by RNA polymerase II
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48568; embryonic organ development
GO:30307; positive regulation of cell growth
GO:65003; protein-containing complex assembly
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:5667; transcription regulator complex
GO:140552; TEAD-YAP complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:987; cis-regulatory region sequence-specific DNA binding
Show all GO terms

Homologs of TEAD1 in Model Organisms

Danio rerio
tead1a
Mus musculus
Tead1
Rattus norvegicus
Tead1

External links

OMIM
189967
Ensembl
ENSG00000187079
Entrez Gene
7003
UniGene
655331
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TEAD1
GeneCards
TEAD1