Cell Senescence Entries for TERF2

Cell Types
Neuroblastoma
Cell Lines
SH-SY5Y
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Zhang et al. (2006) TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. J Neurochem 97(2)567-81 (PubMed)

TERF2 Gene Information

HGNC symbol
TERF2 
Aliases
TRBF2; TRF2 
Common name
telomeric repeat binding factor 2 
Entrez Id
7014
Description
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008].

TERF2 Ontologies

Gene Ontology
Process: GO:2000773; negative regulation of cellular senescence
GO:10628; positive regulation of gene expression
GO:7049; cell cycle
GO:723; telomere maintenance
GO:6278; RNA-dependent DNA biosynthetic process
GO:31848; protection from non-homologous end joining at telomere
GO:10629; negative regulation of gene expression
GO:51000; positive regulation of nitric-oxide synthase activity
GO:1904354; negative regulation of telomere capping
GO:61820; telomeric D-loop disassembly
GO:32210; regulation of telomere maintenance via telomerase
And 20 more GO terms
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:1904115; axon cytoplasm
GO:16604; nuclear body
GO:783; nuclear telomere cap complex
GO:70187; shelterin complex
GO:1673; male germ cell nucleus
GO:43229; intracellular organelle
Function: GO:5515; protein binding
GO:3720; telomerase activity
GO:44877; protein-containing complex binding
GO:3677; DNA binding
GO:42803; protein homodimerization activity
GO:42162; telomeric DNA binding
GO:8022; protein C-terminus binding
GO:19899; enzyme binding
GO:98505; G-rich strand telomeric DNA binding
GO:3691; double-stranded telomeric DNA binding
Show all GO terms

Homologs of TERF2 in Model Organisms

Danio rerio
terfa
Mus musculus
Terf2
Rattus norvegicus
Terf2

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Terf2
GenAge human genes
  • This gene is present as TERF2
LongevityMap
  • This gene is present as TERF2

External links

OMIM
602027
Ensembl
ENSG00000132604
Entrez Gene
7014
UniGene
63335
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TERF2
GeneCards
TERF2