Cell Senescence Entries for TERT
- Cell Types
- Foreskin fibroblast, Retinal pigment epithelial
- Cell Lines
- BJ, RPE-340
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Bodnar et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279(5349)349-52 (PubMed)
TERT Gene Information
- HGNC symbol
- TERT
- Aliases
- EST2; hEST2; TCS1; TP2; TRT
- Common name
- telomerase reverse transcriptase
- Entrez Id
- 7015
- Description
- Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].
TERT Ontologies
- Gene Ontology
-
Process: GO:7004; telomere maintenance via telomerase
GO:71456; cellular response to hypoxia
GO:71897; DNA biosynthetic process
GO:2000773; negative regulation of cellular senescence
GO:723; telomere maintenance
GO:1172; transcription, RNA-templated
GO:6278; RNA-dependent DNA biosynthetic process
GO:7005; mitochondrion organization
GO:10629; negative regulation of gene expression
GO:22616; DNA strand elongation
GO:30177; positive regulation of Wnt signaling pathway
And 25 more GO terms Cellular component: GO:781; chromosome, telomeric region
GO:333; telomerase catalytic core complex
GO:5697; telomerase holoenzyme complex
GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5694; chromosome
GO:5730; nucleolus
GO:16605; PML body
And 7 more GO terms
Show all GO termsFunction: GO:5515; protein binding
GO:3720; telomerase activity
GO:3721; telomerase RNA reverse transcriptase activity
GO:3964; RNA-directed DNA polymerase activity
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:16779; nucleotidyltransferase activity
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:49; tRNA binding
And 10 more GO terms
Homologs of TERT in Model Organisms
- Danio rerio
- tert
- Mus musculus
- Tert
- Rattus norvegicus
- Tert
- Saccharomyces cerevisiae
- EST2
- Schizosaccharomyces pombe
- trt1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Tert
- GenAge human genes
- This gene is present as TERT
- LongevityMap
- This gene is present as TERT
External links
- OMIM
- 187270
- Ensembl
- ENSG00000164362
- Entrez Gene
- 7015
- UniGene
- 492203
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TERT
- GeneCards
- TERT