Cell Senescence Entries for TLR10

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Hari et al. (2020) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv 5(6)eaaw0254 (PubMed)

TLR10 Gene Information

HGNC symbol
TLR10 
Aliases
CD290 
Common name
toll like receptor 10 
Entrez Id
81793
Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010].

TLR10 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:45087; innate immune response
GO:2376; immune system process
GO:6955; immune response
GO:6954; inflammatory response
GO:1817; regulation of cytokine production
GO:2224; toll-like receptor signaling pathway
GO:2755; MyD88-dependent toll-like receptor signaling pathway
GO:34166; toll-like receptor 10 signaling pathway
GO:50729; positive regulation of inflammatory response
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:43235; receptor complex
Function: GO:16787; hydrolase activity
GO:5515; protein binding
GO:4888; transmembrane signaling receptor activity
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:50135; NAD(P)+ nucleosidase activity
GO:61809; NAD+ nucleotidase, cyclic ADP-ribose generating
GO:38023; signaling receptor activity
Show all GO terms

Homologs of TLR10 in Model Organisms

Danio rerio
tlr1
Rattus norvegicus
Tlr10

External links

OMIM
606270
Ensembl
ENSG00000174123
Entrez Gene
81793
UniGene
730896
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TLR10
GeneCards
TLR10