Cell Senescence Entries for TLR4

Cell Types
Lung microvascular endothelial
Cell Lines
HLMVEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2020) Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging Cell 18(3)e12914 (PubMed)

TLR4 Gene Information

HGNC symbol
TLR4 
Aliases
ARMD10; CD284; hToll; TLR-4 
Common name
toll like receptor 4 
Entrez Id
7099
Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020].

TLR4 Ontologies

Gene Ontology
Process: GO:50729; positive regulation of inflammatory response
GO:7165; signal transduction
GO:2376; immune system process
GO:45087; innate immune response
GO:6955; immune response
GO:6954; inflammatory response
GO:2224; toll-like receptor signaling pathway
GO:42742; defense response to bacterium
GO:6909; phagocytosis
GO:71222; cellular response to lipopolysaccharide
GO:10628; positive regulation of gene expression
And 73 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5768; endosome
GO:42995; cell projection
GO:48471; perinuclear region of cytoplasm
GO:5769; early endosome
GO:9986; cell surface
GO:1726; ruffle
And 8 more GO terms
Function: GO:5515; protein binding
GO:16787; hydrolase activity
GO:4888; transmembrane signaling receptor activity
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:50135; NAD(P)+ nucleosidase activity
GO:61809; NAD+ nucleotidase, cyclic ADP-ribose generating
GO:38023; signaling receptor activity
GO:1530; lipopolysaccharide binding
GO:1540; amyloid-beta binding
GO:1875; lipopolysaccharide immune receptor activity
And 3 more GO terms
Show all GO terms

Homologs of TLR4 in Model Organisms

Danio rerio
tlr4bb
Mus musculus
Tlr4
Rattus norvegicus
Tlr4

In other databases

LongevityMap
  • This gene is present as TLR4

External links

OMIM
603030
Ensembl
ENSG00000136869
Entrez Gene
7099
UniGene
174312
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TLR4
GeneCards
TLR4