Cell Senescence Entries for TOM1
- Cell Types
- Lung fibroblast
- Cell Lines
- 2BS
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Guo et al. (2004) Cloning and characterization of cellular senescence-associated genes in human fibroblasts by suppression subtractive hybridization. Exp Cell Res 298(2)465-72 (PubMed)
TOM1 Gene Information
- HGNC symbol
- TOM1
- Aliases
- Common name
- target of myb1 membrane trafficking protein
- Entrez Id
- 10043
- Description
- This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
TOM1 Ontologies
- Gene Ontology
-
Process: GO:15031; protein transport
GO:6897; endocytosis
GO:16197; endosomal transport
GO:7165; signal transduction
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5768; endosome
GO:5829; cytosol
GO:5769; early endosome
GO:5886; plasma membrane
GO:70062; extracellular exosome
GO:35579; specific granule membrane
GO:35577; azurophil granule membrane
Show all GO termsFunction: GO:43130; ubiquitin binding
GO:35091; phosphatidylinositol binding
GO:5515; protein binding
GO:30276; clathrin binding
Homologs of TOM1 in Model Organisms
External links
- OMIM
- 604700
- Ensembl
- ENSG00000100284
- Entrez Gene
- 10043
- UniGene
- 474705
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TOM1
- GeneCards
- TOM1