Cell Senescence Entries for TP53I3

Cell Types
Lung cancer
Cell Lines
A549, H1299
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Li et al. (2017) PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients. J Exp Clin Cancer Res 36(1)39 (PubMed)

TP53I3 Gene Information

HGNC symbol
TP53I3 
Aliases
PIG3 
Common name
tumor protein p53 inducible protein 3 
Entrez Id
9540
Description
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].

TP53I3 Ontologies

Gene Ontology
Process: GO:6739; NADP metabolic process
Cellular component: GO:5829; cytosol
Function: GO:16491; oxidoreductase activity
GO:42803; protein homodimerization activity
GO:48038; quinone binding
GO:70402; NADPH binding
GO:3960; NADPH:quinone reductase activity
Show all GO terms

Homologs of TP53I3 in Model Organisms

Danio rerio
LOC796473
Rattus norvegicus
uncharacterized_M0R9

External links

OMIM
605171
Ensembl
ENSG00000115129
Entrez Gene
9540
UniGene
733381
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TP53I3
GeneCards
TP53I3