Cell Senescence Entries for TPR
- Cell Types
- Cervical cancer, Melanoma, Osteosarcoma
- Cell Lines
- A375, HeLa, U2OS
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- David-Watine et al. (2011) Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells. PLoS One 6(7)e22423 (PubMed)
TPR Gene Information
- HGNC symbol
- TPR
- Aliases
- Common name
- translocated promoter region, nuclear basket protein
- Entrez Id
- 7175
- Description
- This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008].
TPR Ontologies
- Gene Ontology
-
Process: GO:51028; mRNA transport
GO:15031; protein transport
GO:7049; cell cycle
GO:51301; cell division
GO:122; negative regulation of transcription by RNA polymerase II
GO:32880; regulation of protein localization
GO:42307; positive regulation of protein import into nucleus
GO:6606; protein import into nucleus
GO:6406; mRNA export from nucleus
GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:90316; positive regulation of intracellular protein transport
And 16 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5856; cytoskeleton
GO:5635; nuclear envelope
GO:31965; nuclear membrane
GO:5694; chromosome
GO:5643; nuclear pore
GO:775; chromosome, centromeric region
GO:5819; spindle
GO:5868; cytoplasmic dynein complex
And 8 more GO terms
Show all GO termsFunction: GO:3723; RNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:3729; mRNA binding
GO:70840; dynein complex binding
GO:3682; chromatin binding
GO:17056; structural constituent of nuclear pore
GO:15631; tubulin binding
GO:51019; mitogen-activated protein kinase binding
GO:31072; heat shock protein binding
Homologs of TPR in Model Organisms
- Caenorhabditis elegans
- npp-21
- Danio rerio
- tprb
- Drosophila melanogaster
- Mtor
- Mus musculus
- Tpr
- Rattus norvegicus
- Tpr
- Saccharomyces cerevisiae
- MLP2
- Schizosaccharomyces pombe
- nup211
External links
- OMIM
- 189940
- Ensembl
- ENSG00000047410
- Entrez Gene
- 7175
- UniGene
- 279640
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TPR
- GeneCards
- TPR