Cell Senescence Entries for TPX2

Cell Types
Liver cancer
Cell Lines
Ha22T, SK-HEP-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Hsu et al. (2020) Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability. J Cancer 8(8)1378-1394 (PubMed)

TPX2 Gene Information

HGNC symbol
TPX2 
Aliases
C20orf1; C20orf2; DIL-2; p100 
Common name
TPX2 microtubule nucleation factor 
Entrez Id
22974
Description

TPX2 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6915; apoptotic process
GO:51301; cell division
GO:90307; mitotic spindle assembly
GO:278; mitotic cell cycle
GO:32147; activation of protein kinase activity
GO:7026; negative regulation of microtubule depolymerization
GO:60236; regulation of mitotic spindle organization
GO:7020; microtubule nucleation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:45171; intercellular bridge
GO:5856; cytoskeleton
GO:5874; microtubule
GO:72686; mitotic spindle
GO:5819; spindle
GO:922; spindle pole
GO:5829; cytosol
GO:15630; microtubule cytoskeleton
And 3 more GO terms
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:8017; microtubule binding
GO:30295; protein kinase activator activity
GO:61676; importin-alpha family protein binding
Show all GO terms

Homologs of TPX2 in Model Organisms

Danio rerio
tpx2
Mus musculus
Tpx2
Rattus norvegicus
Tpx2

In other databases

CellAge gene expression
  • This gene is present as TPX2

External links

OMIM
605917
Ensembl
ENSG00000088325
Entrez Gene
22974
UniGene
244580
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TPX2
GeneCards
TPX2