Cell Senescence Entries for TRPM8

Cell Types
Pancreatic cancer
Cell Lines
BxPC-3, PANC-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Yee et al. (2015) TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target. Cancer Biol Ther 13(8)592-9 (PubMed)

TRPM8 Gene Information

HGNC symbol
TRPM8 
Aliases
 
Common name
transient receptor potential cation channel subfamily M member 8 
Entrez Id
79054
Description

TRPM8 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:34220; ion transmembrane transport
GO:50896; response to stimulus
GO:6812; cation transport
GO:16048; detection of temperature stimulus
GO:50951; sensory perception of temperature stimulus
GO:70588; calcium ion transmembrane transport
GO:120162; positive regulation of cold-induced thermogenesis
GO:19722; calcium-mediated signaling
GO:98655; cation transmembrane transport
And 6 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:45121; membrane raft
GO:5887; integral component of plasma membrane
GO:9897; external side of plasma membrane
Function: GO:5216; ion channel activity
GO:5515; protein binding
GO:5262; calcium channel activity
GO:5261; cation channel activity
GO:99604; ligand-gated calcium channel activity
GO:42802; identical protein binding
Show all GO terms

Homologs of TRPM8 in Model Organisms

Mus musculus
Trpm8
Rattus norvegicus
Trpm8

External links

OMIM
606678
Ensembl
ENSG00000144481
Entrez Gene
79054
UniGene
366053
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TRPM8
GeneCards
TRPM8