Cell Senescence Entries for TWIST1

Cell Types
Lung cancer
Cell Lines
A549, H460, H727
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Tran et al. (2012) Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8(5)e1002650 (PubMed)
Cell Types
Lung cancer
Cell Lines
A549, H460, H727
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Wang et al. (2014) Twist2, the key Twist isoform related to prognosis, promotes invasion of cervical cancer by inducing epithelial-mesenchymal transition and blocking senescence. Hum Pathol 45(9)1839-46 (PubMed)

TWIST1 Gene Information

HGNC symbol
TWIST1 
Aliases
ACS3; bHLHa38; BPES2; BPES3; CRS; CRS1; H-twist; SCS; TWIST 
Common name
twist family bHLH transcription factor 1 
Entrez Id
7291
Description
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Jul 2020].

TWIST1 Ontologies

Gene Ontology
Process: GO:71456; cellular response to hypoxia
GO:2000773; negative regulation of cellular senescence
GO:10628; positive regulation of gene expression
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:7517; muscle organ development
GO:48511; rhythmic process
GO:6357; regulation of transcription by RNA polymerase II
GO:32502; developmental process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32755; positive regulation of interleukin-6 production
And 54 more GO terms
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:46983; protein dimerization activity
GO:3677; DNA binding
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:140297; DNA-binding transcription factor binding
GO:43425; bHLH transcription factor binding
GO:70888; E-box binding
GO:1221; transcription coregulator binding
GO:3700; DNA-binding transcription factor activity
GO:19904; protein domain specific binding
And 3 more GO terms
Show all GO terms

Homologs of TWIST1 in Model Organisms

Caenorhabditis elegans
lin-32
Drosophila melanogaster
Fer2
Mus musculus
Twist1
Rattus norvegicus
Twist1

In other databases

CellAge gene expression
  • This gene is present as TWIST1

External links

OMIM
601622
Ensembl
ENSG00000122691
Entrez Gene
7291
UniGene
644998
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TWIST1
GeneCards
TWIST1