Cell Senescence Entries for TXNIP
- Cell Types
- Lung fibroblast
- Cell Lines
- 2BS
- Cancer Cell?
- No
- Method
- Knockout, Overexpression
- Type of senescence
- Oncogene-induced, Replicative
- Senescence Effect
- Induces
- Primary Reference
- Zhuo et al. (2010) Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts. J Biol Chem 285(41)31491-501 (PubMed)
TXNIP Gene Information
- HGNC symbol
- TXNIP
- Aliases
- ARRDC6; EST01027; HHCPA78; THIF; VDUP1
- Common name
- thioredoxin interacting protein
- Entrez Id
- 10628
- Description
- This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
TXNIP Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:43086; negative regulation of catalytic activity
GO:15031; protein transport
GO:30216; keratinocyte differentiation
GO:51782; negative regulation of cell division
GO:71228; cellular response to tumor cell
GO:122; negative regulation of transcription by RNA polymerase II
GO:6606; protein import into nucleus
GO:6979; response to oxidative stress
GO:9410; response to xenobiotic stimulus
GO:9612; response to mechanical stimulus
And 9 more GO terms Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5634; nucleus
GO:5758; mitochondrial intermembrane space
Show all GO termsFunction: GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:4857; enzyme inhibitor activity
Homologs of TXNIP in Model Organisms
- Caenorhabditis elegans
- arrd-6
- Danio rerio
- txnipb
- Drosophila melanogaster
- CG2641
- Mus musculus
- Txnip
- Rattus norvegicus
- Txnip
In other databases
- GenAge microarray genes
- This gene is present as TXNIP
- CellAge gene expression
- This gene is present as TXNIP
External links
- OMIM
- 606599
- Ensembl
- ENSG00000265972
- Entrez Gene
- 10628
- UniGene
- 709057
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TXNIP
- GeneCards
- TXNIP