Cell Senescence Entries for UBE2I

Cell Types
Osteosarcoma
Cell Lines
U2OS
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
McManus et al. (2019) Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9. Sci Rep 8(1)7754 (PubMed)

UBE2I Gene Information

HGNC symbol
UBE2I 
Aliases
UBC9 
Common name
ubiquitin conjugating enzyme E2 I 
Entrez Id
7329
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

UBE2I Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:16925; protein sumoylation
GO:7059; chromosome segregation
GO:122; negative regulation of transcription by RNA polymerase II
GO:6464; cellular protein modification process
GO:45892; negative regulation of transcription, DNA-templated
GO:6511; ubiquitin-dependent protein catabolic process
GO:7084; mitotic nuclear membrane reassembly
GO:1903755; positive regulation of SUMO transferase activity
GO:51168; nuclear export
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:32446; protein modification by small protein conjugation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16605; PML body
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5635; nuclear envelope
GO:5643; nuclear pore
GO:106068; SUMO ligase complex
GO:795; synaptonemal complex
GO:1990234; transferase complex
GO:1990356; sumoylated E2 ligase complex
GO:16604; nuclear body
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16740; transferase activity
GO:19899; enzyme binding
GO:19789; SUMO transferase activity
GO:8134; transcription factor binding
GO:1221; transcription coregulator binding
GO:71535; RING-like zinc finger domain binding
GO:44388; small protein activating enzyme binding
GO:61656; SUMO conjugating enzyme activity
GO:43398; HLH domain binding
GO:19787; ubiquitin-like protein transferase activity
Hide GO terms

Homologs of UBE2I in Model Organisms

Caenorhabditis elegans
ubc-9
Danio rerio
ube2ib
Drosophila melanogaster
lwr
Mus musculus
Ube2i
Rattus norvegicus
Ube2i
Saccharomyces cerevisiae
UBC9
Schizosaccharomyces pombe
hus5

In other databases

GenAge human genes
  • This gene is present as UBE2I

External links

OMIM
601661
Ensembl
ENSG00000103275
Entrez Gene
7329
UniGene
302903
1000 Genomes
1000 Genomes
HPRD
GenAtlas
UBE2I
GeneCards
UBE2I