Cell Senescence Entries for UBE2V2

Cell Types
Melanoma
Cell Lines
A2058, A375
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Dikshit et al. (2019) UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling. Cancer Res 78(22)6462-6472 (PubMed)

UBE2V2 Gene Information

HGNC symbol
UBE2V2 
Aliases
DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2 
Common name
ubiquitin conjugating enzyme E2 V2 
Entrez Id
7336
Description
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008].

UBE2V2 Ontologies

Gene Ontology
Process: GO:209; protein polyubiquitination
GO:42275; error-free postreplication DNA repair
GO:70534; protein K63-linked ubiquitination
GO:16567; protein ubiquitination
GO:729; DNA double-strand break processing
GO:6282; regulation of DNA repair
GO:6301; postreplication repair
GO:1902523; positive regulation of protein K63-linked ubiquitination
GO:2000781; positive regulation of double-strand break repair
Cellular component: GO:5654; nucleoplasm
GO:5634; nucleus
GO:70062; extracellular exosome
GO:5737; cytoplasm
GO:31372; UBC13-MMS2 complex
Function: GO:5515; protein binding
Show all GO terms

Homologs of UBE2V2 in Model Organisms

Caenorhabditis elegans
uev-1
Danio rerio
ube2v2
Drosophila melanogaster
Uev1A
Mus musculus
Ube2v2
Rattus norvegicus
Ube2v2
Schizosaccharomyces pombe
spm2

External links

OMIM
603001
Ensembl
ENSG00000169139
Entrez Gene
7336
UniGene
595400
1000 Genomes
1000 Genomes
HPRD
GenAtlas
UBE2V2
GeneCards
UBE2V2