The UBTD1 gene and its putative association with human ageing

Cell Senescence Entries for UBTD1

Cell Types: Breast cancer, Colorectal cancer, Gastric cancer, Gastric epithelial, Lung fibroblast, Prostate cancer
Cell Lines: AGS, GES-1, KATO-III, LoVo, MCF-7, MKN28, MKN45, MRC-5, NCI-N87, PC-3, SGC-7901, SNU-1, SNU-16
Cancer Cell?: Yes
Method: Overexpression
Type of senescence: Replicative, Stress-induced
Senescence Effect: Induces
Primary Reference: Zhang et al. (2015) UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop. J Pathol 235(4)656-67 (PubMed)

HGNC symbol: UBTD1
Aliases: FLJ11807
Common name: ubiquitin domain containing 1
Entrez Id: 80019
Description: The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014].

Gene Ontology

Process:

Cellular component:

Function:

GO:5515; protein binding

Show all GO terms