Cell Senescence Entries for USP1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Ogrunc et al. (2017) RETRACTED: USP1 Regulates Cellular Senescence by Controlling Genomic Integrity. Cell Rep 15(7)1401-1411 (PubMed)

USP1 Gene Information

HGNC symbol
USP1 
Aliases
 
Common name
ubiquitin specific peptidase 1 
Entrez Id
7398
Description
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

USP1 Ontologies

Gene Ontology
Process: GO:16579; protein deubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:6508; proteolysis
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:9411; response to UV
GO:1501; skeletal system development
GO:6282; regulation of DNA repair
GO:35520; monoubiquitinated protein deubiquitination
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:4843; thiol-dependent deubiquitinase
GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4197; cysteine-type endopeptidase activity
Show all GO terms

Homologs of USP1 in Model Organisms

Danio rerio
usp1
Drosophila melanogaster
BcDNA.LD22910
Mus musculus
Usp1
Rattus norvegicus
Usp1

In other databases

CellAge gene expression
  • This gene is present as USP1

External links

OMIM
603478
Ensembl
ENSG00000162607
Entrez Gene
7398
UniGene
35086
1000 Genomes
1000 Genomes
HPRD
GenAtlas
USP1
GeneCards
USP1