Cell Senescence Entries for USP28

Cell Types
Retinal pigment epithelial
Cell Lines
RPE-1
Cancer Cell?
No
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Fong et al. (2017) 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis. Elife 5(2)117-26 (PubMed)

USP28 Gene Information

HGNC symbol
USP28 
Aliases
KIAA1515 
Common name
ubiquitin specific peptidase 28 
Entrez Id
57646
Description
The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016].

USP28 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:16579; protein deubiquitination
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6511; ubiquitin-dependent protein catabolic process
GO:10212; response to ionizing radiation
GO:7265; Ras protein signal transduction
GO:31647; regulation of protein stability
GO:77; DNA damage checkpoint signaling
GO:34644; cellular response to UV
GO:42771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:16604; nuclear body
GO:5829; cytosol
Function: GO:4843; thiol-dependent deubiquitinase
GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4197; cysteine-type endopeptidase activity
Show all GO terms

Homologs of USP28 in Model Organisms

Caenorhabditis elegans
K02C4.3
Mus musculus
Usp28
Rattus norvegicus
Usp28

External links

OMIM
610748
Ensembl
ENSG00000048028
Entrez Gene
57646
UniGene
503891
1000 Genomes
1000 Genomes
HPRD
GenAtlas
USP28
GeneCards
USP28