Cell Senescence Entries for VCAN

Cell Types
Umbilical vein endothelial, Vascular smooth muscle
Cell Lines
HUVEC, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Li et al. (2022) Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells. Cell Biosci 9(2)1 (PubMed)

VCAN Gene Information

HGNC symbol
VCAN 
Aliases
CSPG2; PG-M 
Common name
versican 
Entrez Id
1462
Description
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].

VCAN Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:6024; glycosaminoglycan biosynthetic process
GO:6027; glycosaminoglycan catabolic process
GO:7417; central nervous system development
GO:1501; skeletal system development
GO:7275; multicellular organism development
GO:1649; osteoblast differentiation
GO:8037; cell recognition
GO:8347; glial cell migration
Cellular component: GO:5615; extracellular space
GO:16020; membrane
GO:5576; extracellular region
GO:42995; cell projection
GO:12505; endomembrane system
GO:43202; lysosomal lumen
GO:33165; interphotoreceptor matrix
GO:31012; extracellular matrix
GO:62023; collagen-containing extracellular matrix
GO:1750; photoreceptor outer segment
GO:5788; endoplasmic reticulum lumen
And 2 more GO terms
Function: GO:30246; carbohydrate binding
GO:5509; calcium ion binding
GO:5515; protein binding
GO:5540; hyaluronic acid binding
GO:30021; extracellular matrix structural constituent conferring compression resistance
GO:5539; glycosaminoglycan binding
Show all GO terms

Homologs of VCAN in Model Organisms

Mus musculus
Vcan
Rattus norvegicus
Vcan

External links

OMIM
118661
Ensembl
ENSG00000038427
Entrez Gene
1462
UniGene
643801
1000 Genomes
1000 Genomes
HPRD
GenAtlas
VCAN
GeneCards
VCAN