Cell Senescence Entries for WEE1

Cell Types
Melanoma
Cell Lines
A375P
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

WEE1 Gene Information

HGNC symbol
WEE1 
Aliases
WEE1A 
Common name
WEE1 G2 checkpoint kinase 
Entrez Id
7465
Description
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008].

WEE1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:278; mitotic cell cycle
GO:86; G2/M transition of mitotic cell cycle
GO:226; microtubule cytoskeleton organization
GO:18108; peptidyl-tyrosine phosphorylation
GO:30010; establishment of cell polarity
GO:48812; neuron projection morphogenesis
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
And 1 more GO terms
Cellular component: GO:5634; nucleus
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5737; cytoplasm
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:5524; ATP binding
GO:46872; metal ion binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:287; magnesium ion binding
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:4715; non-membrane spanning protein tyrosine kinase activity
And 1 more GO terms
Show all GO terms

Homologs of WEE1 in Model Organisms

Danio rerio
wee1
Mus musculus
Wee1
Rattus norvegicus
Wee1

In other databases

GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Wee1

External links

OMIM
193525
Ensembl
ENSG00000166483
Entrez Gene
7465
UniGene
249441
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WEE1
GeneCards
WEE1