Cell Senescence Entries for WIF1
- Cell Types
- Salivary gland
- Cell Lines
- CaExPA79
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Ramachandran et al. (2014) Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence. Cell Death Dis 5(2)e1246 (PubMed)
WIF1 Gene Information
- HGNC symbol
- WIF1
- Aliases
- Common name
- WNT inhibitory factor 1
- Entrez Id
- 11197
- Description
- The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010].
WIF1 Ontologies
- Gene Ontology
-
Process: GO:16055; Wnt signaling pathway
GO:48856; anatomical structure development
GO:7165; signal transduction
GO:30178; negative regulation of Wnt signaling pathway
GO:45600; positive regulation of fat cell differentiation
Cellular component: GO:5576; extracellular region
GO:9986; cell surface
Show all GO termsFunction: GO:5515; protein binding
GO:5102; signaling receptor binding
GO:17147; Wnt-protein binding
Homologs of WIF1 in Model Organisms
External links
- OMIM
- 605186
- Ensembl
- ENSG00000156076
- Entrez Gene
- 11197
- UniGene
- 284122
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- WIF1
- GeneCards
- WIF1