Cell Senescence Entries for WIPI1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Xiao et al. (2019) Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Res 28(11)1601-1610 (PubMed)

WIPI1 Gene Information

HGNC symbol
WIPI1 
Aliases
ATG18; ATG18A; FLJ10055; WIPI49 
Common name
WD repeat domain, phosphoinositide interacting 1 
Entrez Id
55062
Description
This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

WIPI1 Ontologies

Gene Ontology
Process: GO:6914; autophagy
GO:45; autophagosome assembly
GO:422; autophagy of mitochondrion
GO:9267; cellular response to starvation
GO:34497; protein localization to phagophore assembly site
GO:44804; autophagy of nucleus
GO:2000786; positive regulation of autophagosome assembly
GO:6497; protein lipidation
GO:48203; vesicle targeting, trans-Golgi to endosome
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:407; phagophore assembly site
GO:5768; endosome
GO:5856; cytoskeleton
GO:10008; endosome membrane
GO:5802; trans-Golgi network
GO:421; autophagosome membrane
GO:34045; phagophore assembly site membrane
And 5 more GO terms
Function: GO:8289; lipid binding
GO:32266; phosphatidylinositol-3-phosphate binding
GO:5515; protein binding
GO:80025; phosphatidylinositol-3,5-bisphosphate binding
GO:30331; estrogen receptor binding
GO:50681; androgen receptor binding
GO:5102; signaling receptor binding
Show all GO terms

Homologs of WIPI1 in Model Organisms

Caenorhabditis elegans
atg-18
Danio rerio
LOC100332293
Drosophila melanogaster
Atg18
Mus musculus
Wipi1
Rattus norvegicus
Wipi1
Saccharomyces cerevisiae
ATG21
Schizosaccharomyces pombe
atg18

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as atg-18
  • A homolog of this gene for Saccharomyces cerevisiae is present as ATG21

External links

OMIM
609224
Ensembl
ENSG00000070540
Entrez Gene
55062
UniGene
463964
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WIPI1
GeneCards
WIPI1