Cell Senescence Entries for WNT16

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Binet et al. (2010) WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res 69(24)9183-91 (PubMed)

WNT16 Gene Information

HGNC symbol
WNT16 
Aliases
 
Common name
Wnt family member 16 
Entrez Id
51384
Description
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008].

WNT16 Ontologies

Gene Ontology
Process: GO:16055; Wnt signaling pathway
GO:7275; multicellular organism development
GO:10628; positive regulation of gene expression
GO:30182; neuron differentiation
GO:60070; canonical Wnt signaling pathway
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:46330; positive regulation of JNK cascade
GO:45165; cell fate commitment
GO:90399; replicative senescence
GO:60548; negative regulation of cell death
GO:90403; oxidative stress-induced premature senescence
And 6 more GO terms
Cellular component: GO:5576; extracellular region
GO:5737; cytoplasm
GO:5615; extracellular space
Function: GO:5102; signaling receptor binding
GO:5125; cytokine activity
GO:5109; frizzled binding
Show all GO terms

Homologs of WNT16 in Model Organisms

Caenorhabditis elegans
egl-20
Danio rerio
wnt16
Mus musculus
Wnt16
Rattus norvegicus
Wnt16

External links

OMIM
606267
Ensembl
ENSG00000002745
Entrez Gene
51384
UniGene
272375
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WNT16
GeneCards
WNT16