Cell Senescence Entries for WNT5A

Cell Types
Ovarian cancer
Cell Lines
OVCAR5, PEO1
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Bitler et al. (2011) Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res 71(19)6184-94 (PubMed)

WNT5A Gene Information

HGNC symbol
WNT5A 
Aliases
hWNT5A 
Common name
Wnt family member 5A 
Entrez Id
7474
Description
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

WNT5A Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:16055; Wnt signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:10033; response to organic substance
GO:51216; cartilage development
GO:1667; ameboidal-type cell migration
GO:1736; establishment of planar polarity
GO:1756; somitogenesis
GO:1819; positive regulation of cytokine production
And 169 more GO terms
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5886; plasma membrane
GO:98794; postsynapse
GO:9986; cell surface
GO:31012; extracellular matrix
GO:62023; collagen-containing extracellular matrix
GO:5788; endoplasmic reticulum lumen
GO:30666; endocytic vesicle membrane
GO:5796; Golgi lumen
GO:98978; glutamatergic synapse
And 3 more GO terms
Function: GO:5102; signaling receptor binding
GO:5515; protein binding
GO:5109; frizzled binding
GO:5125; cytokine activity
GO:19904; protein domain specific binding
GO:1902379; chemoattractant activity involved in axon guidance
GO:48018; receptor ligand activity
GO:5115; receptor tyrosine kinase-like orphan receptor binding
GO:5543; phospholipid binding
Show all GO terms

Homologs of WNT5A in Model Organisms

Caenorhabditis elegans
wnt-2
Danio rerio
wnt5b
Mus musculus
Wnt5a
Rattus norvegicus
Wnt5a

In other databases

CellAge gene expression
  • This gene is present as WNT5A

External links

OMIM
164975
Ensembl
ENSG00000114251
Entrez Gene
7474
UniGene
643085
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WNT5A
GeneCards
WNT5A