Cell Senescence Entries for WNT7B

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown, Mutation
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)

WNT7B Gene Information

HGNC symbol
WNT7B 
Aliases
 
Common name
Wnt family member 7B 
Entrez Id
7477
Description
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008].

WNT7B Ontologies

Gene Ontology
Process: GO:16055; Wnt signaling pathway
GO:30182; neuron differentiation
GO:71300; cellular response to retinoic acid
GO:60070; canonical Wnt signaling pathway
GO:46330; positive regulation of JNK cascade
GO:50808; synapse organization
GO:42592; homeostatic process
GO:45165; cell fate commitment
GO:70307; lens fiber cell development
GO:1701; in utero embryonic development
GO:60425; lung morphogenesis
And 32 more GO terms
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
GO:5886; plasma membrane
GO:5788; endoplasmic reticulum lumen
GO:30666; endocytic vesicle membrane
GO:5796; Golgi lumen
GO:70062; extracellular exosome
GO:5737; cytoplasm
Function: GO:5102; signaling receptor binding
GO:5515; protein binding
GO:5125; cytokine activity
GO:5109; frizzled binding
GO:48018; receptor ligand activity
Show all GO terms

Homologs of WNT7B in Model Organisms

Danio rerio
wnt7ba
Mus musculus
Wnt7b
Rattus norvegicus
Wnt7b

External links

OMIM
601967
Ensembl
ENSG00000188064
Entrez Gene
7477
UniGene
512714
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WNT7B
GeneCards
WNT7B