Cell Senescence Entries for WT1

Cell Types
Lung cancer
Cell Lines
NCI-A549, NCI-H1299, NCI-H1437, NCI-H1568, NCI-H1650, NCI-H1975, NCI-H2009, NCI-H2126, NCI-H23, NCI-H358, NCI-H441, NCI-H460, NCI-H522, NCI-H727
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Vicent et al. (2010) Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. J Clin Invest 120(11)3940-52 (PubMed)

WT1 Gene Information

HGNC symbol
WT1 
Aliases
AWT1; GUD; NPHS4; WAGR; WIT-2 
Common name
WT1 transcription factor 
Entrez Id
7490
Description
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015].

WT1 Ontologies

Gene Ontology
Process: GO:8380; RNA splicing
GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:1822; kidney development
GO:6357; regulation of transcription by RNA polymerase II
GO:7507; heart development
GO:8285; negative regulation of cell population proliferation
GO:30308; negative regulation of cell growth
GO:8584; male gonad development
And 38 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5730; nucleolus
Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:10385; double-stranded methylated DNA binding
And 4 more GO terms
Show all GO terms

Homologs of WT1 in Model Organisms

Danio rerio
wt1a
Mus musculus
Wt1
Rattus norvegicus
Wt1
Schizosaccharomyces pombe
SPAC25B8.19c

External links

OMIM
607102
Ensembl
ENSG00000184937
Entrez Gene
7490
UniGene
591980
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WT1
GeneCards
WT1