Cell Senescence Entries for WWP1

Cell Types
Lung fibroblast
Cell Lines
2BS, WI-38
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Cao et al. (2011) WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts. J Biol Chem 286(38)33447-56 (PubMed)

WWP1 Gene Information

HGNC symbol
WWP1 
Aliases
AIP5; DKFZP434D2111 
Common name
WW domain containing E3 ubiquitin protein ligase 1 
Entrez Id
11059
Description
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008].

WWP1 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:45892; negative regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:6511; ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:34220; ion transmembrane transport
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:45732; positive regulation of protein catabolic process
GO:46718; viral entry into host cell
GO:7417; central nervous system development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:70062; extracellular exosome
GO:151; ubiquitin ligase complex
Function: GO:16740; transferase activity
GO:4842; ubiquitin-protein transferase activity
GO:5515; protein binding
GO:61630; ubiquitin protein ligase activity
Show all GO terms

Homologs of WWP1 in Model Organisms

Mus musculus
Wwp1
Rattus norvegicus
Wwp1

External links

OMIM
602307
Ensembl
ENSG00000123124
Entrez Gene
11059
UniGene
655189
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WWP1
GeneCards
WWP1