Cell Senescence Entries for YAP1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Xie et al. (2013) YAP/TEAD-mediated transcription controls cellular senescence. Cancer Res 73(12)3615-24 (PubMed)

YAP1 Gene Information

HGNC symbol
YAP1 
Aliases
YAP65 
Common name
Yes1 associated transcriptional regulator 
Entrez Id
10413
Description
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].

YAP1 Ontologies

Gene Ontology
Process: GO:6974; cellular response to DNA damage stimulus
GO:122; negative regulation of transcription by RNA polymerase II
GO:35329; hippo signaling
GO:45944; positive regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:45747; positive regulation of Notch signaling pathway
GO:33148; positive regulation of intracellular estrogen receptor signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:1902018; negative regulation of cilium assembly
GO:8283; cell population proliferation
GO:70102; interleukin-6-mediated signaling pathway
And 46 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:30054; cell junction
GO:5829; cytosol
GO:140552; TEAD-YAP complex
GO:1674; female germ cell nucleus
GO:5667; transcription regulator complex
GO:16020; membrane
Function: GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:976; transcription cis-regulatory region binding
GO:3714; transcription corepressor activity
GO:140297; DNA-binding transcription factor binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:8022; protein C-terminus binding
GO:70064; proline-rich region binding
Show all GO terms

Homologs of YAP1 in Model Organisms

Danio rerio
yap1
Mus musculus
Yap1
Rattus norvegicus
Yap1

External links

OMIM
606608
Ensembl
ENSG00000137693
Entrez Gene
10413
UniGene
503692
1000 Genomes
1000 Genomes
HPRD
GenAtlas
YAP1
GeneCards
YAP1