Cell Senescence Entries for ZEB1

Cell Types
Colorectal cancer
Cell Lines
SW480, SW620
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Inhibits
Primary Reference
de Barrios et al. (2017) ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1. Gut 66(4)666-682 (PubMed)

ZEB1 Gene Information

HGNC symbol
ZEB1 
Aliases
AREB6; BZP; FECD6; NIL-2-A; PPCD3; TCF8; ZEB; Zfhep; Zfhx1a 
Common name
zinc finger E-box binding homeobox 1 
Entrez Id
6935
Description
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010].

ZEB1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:7399; nervous system development
GO:6357; regulation of transcription by RNA polymerase II
GO:48856; anatomical structure development
GO:122; negative regulation of transcription by RNA polymerase II
GO:45666; positive regulation of neuron differentiation
GO:45602; negative regulation of endothelial cell differentiation
GO:6355; regulation of transcription, DNA-templated
GO:7389; pattern specification process
GO:7417; central nervous system development
And 20 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:43226; organelle
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:70888; E-box binding
GO:3700; DNA-binding transcription factor activity
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:8270; zinc ion binding
GO:3682; chromatin binding
GO:3690; double-stranded DNA binding
And 2 more GO terms
Show all GO terms

Homologs of ZEB1 in Model Organisms

Danio rerio
zeb1b
Mus musculus
Zeb1
Rattus norvegicus
Zeb1

External links

OMIM
189909
Ensembl
ENSG00000148516
Entrez Gene
6935
UniGene
124503
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ZEB1
GeneCards
ZEB1