Cell Senescence Entries for CBX8
- Cell Types
- Fibroblast
- Cell Lines
- TIG-3
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Dietrich et al. (2007) Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J 26(6)1637-48 (PubMed)
CBX8 Gene Information
- HGNC symbol
- CBX8
- Aliases
- HPC3; PC3; RC1
- Common name
- chromobox 8
- Entrez Id
- 57332
- Description
CBX8 Ontologies
- Gene Ontology
-
Process: GO:50790; regulation of catalytic activity
GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:16574; histone ubiquitination
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:31519; PcG protein complex
GO:35102; PRC1 complex
GO:151; ubiquitin ligase complex
GO:792; heterochromatin
Show all GO termsFunction: GO:5515; protein binding
GO:35064; methylated histone binding
GO:3727; single-stranded RNA binding
GO:97027; ubiquitin-protein transferase activator activity
Homologs of CBX8 in Model Organisms
External links
- OMIM
- 617354
- Ensembl
- ENSG00000141570
- Entrez Gene
- 57332
- UniGene
- 387258
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CBX8
- GeneCards
- CBX8