Cell Senescence Entries for CCN6

Cell Types
Fetal lung fibroblast, Umbilical cord fibroblast
Cell Lines
HUC-F2, TIG-1
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Udono et al. (2016) Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cells. Sci Rep 5(2)17342 (PubMed)

CCN6 Gene Information

HGNC symbol
CCN6 
Aliases
WISP-3; WISP3 
Common name
cellular communication network factor 6 
Entrez Id
8838
Description
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

CCN6 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:50793; regulation of developmental process
GO:7155; cell adhesion
GO:7267; cell-cell signaling
GO:60548; negative regulation of cell death
GO:8285; negative regulation of cell population proliferation
GO:16525; negative regulation of angiogenesis
GO:51881; regulation of mitochondrial membrane potential
GO:1903426; regulation of reactive oxygen species biosynthetic process
Cellular component: GO:5576; extracellular region
GO:5739; mitochondrion
GO:5615; extracellular space
GO:31012; extracellular matrix
Function: GO:8083; growth factor activity
GO:5178; integrin binding
GO:8201; heparin binding
Show all GO terms

Homologs of CCN6 in Model Organisms

Danio rerio
wisp3
Mus musculus
Wisp3
Rattus norvegicus
Wisp3

External links

OMIM
603400
Ensembl
ENSG00000112761
Entrez Gene
8838
UniGene
558428
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CCN6
GeneCards
CCN6