Cell Senescence Entries for IRF7

Cell Types
Li Fraumeni syndrome fibroblast
Cell Lines
MDAH041
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of IRF7 in immortal MDAH041 cells resulted in reduced proliferation rates, reduced cell growth, and increased senescence-associated beta-galactosidase activity.
Primary Reference

    IRF7 Gene Information

    HGNC symbol
    IRF7 
    Aliases
    IMD39; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H 
    Common name
    interferon regulatory factor 7 
    Entrez Id
    3665
    Description
    IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

    IRF7 Ontologies

    Gene Ontology
    Process: GO:39530; MDA-5 signaling pathway
    GO:35666; TRIF-dependent toll-like receptor signaling pathway
    GO:6974; cellular response to DNA damage stimulus
    GO:19043; establishment of viral latency
    GO:16064; immunoglobulin mediated immune response
    GO:45087; innate immune response
    GO:32607; interferon-alpha production
    GO:32608; interferon-beta production
    GO:60333; interferon-gamma-mediated signaling pathway
    GO:2000110; negative regulation of macrophage apoptotic process
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    And 17 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:10008; endosome membrane
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:979; RNA polymerase II core promoter sequence-specific DNA binding
    GO:5515; protein binding
    GO:982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of IRF7 in Model Organisms

    Danio rerio
    irf7
    Mus musculus
    Irf7
    Rattus norvegicus
    Irf7

    In other databases

    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Irf7

    External links

    OMIM
    605047
    Ensembl
    ENSG00000185507
    Entrez Gene
    3665
    UniGene
    166120
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    IRF7
    GeneCards
    IRF7