Cell Senescence Entries for CCNB1

Cell Types
Pancreatic cancer, Primary cell
Cell Lines
Primary cell
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Zhang et al. (2019) Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. J Cell Physiol 234(1)619-631 (PubMed)

CCNB1 Gene Information

HGNC symbol
CCNB1 
Aliases
CCNB 
Common name
cyclin B1 
Entrez Id
891
Description
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017].

CCNB1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:45931; positive regulation of mitotic cell cycle
GO:7052; mitotic spindle organization
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:44772; mitotic cell cycle phase transition
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:1905448; positive regulation of mitochondrial ATP synthesis coupled electron transport
GO:1701; in utero embryonic development
GO:6468; protein phosphorylation
And 6 more GO terms
Cellular component: GO:5829; cytosol
GO:5737; cytoplasm
GO:5634; nucleus
GO:5856; cytoskeleton
GO:5815; microtubule organizing center
GO:5813; centrosome
GO:5759; mitochondrial matrix
GO:5654; nucleoplasm
GO:940; outer kinetochore
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:97125; cyclin B1-CDK1 complex
And 3 more GO terms
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:44389; ubiquitin-like protein ligase binding
GO:16538; cyclin-dependent protein serine/threonine kinase regulator activity
GO:5113; patched binding
GO:61575; cyclin-dependent protein serine/threonine kinase activator activity
Show all GO terms

Homologs of CCNB1 in Model Organisms

Danio rerio
ccnb1
Mus musculus
Ccnb1
Rattus norvegicus
Ccnb1
Saccharomyces cerevisiae
CLB1
Schizosaccharomyces pombe
cig2

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as CLB1
CellAge gene expression
  • This gene is present as CCNB1

External links

OMIM
123836
Ensembl
ENSG00000134057
Entrez Gene
891
UniGene
23960
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CCNB1
GeneCards
CCNB1