Cell Senescence Entries for CDC45
- Cell Types
- Melanoma
- Cell Lines
- A375P
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)
CDC45 Gene Information
- HGNC symbol
- CDC45
- Aliases
- CDC45L; CDC45L2
- Common name
- cell division cycle 45
- Entrez Id
- 8318
- Description
- The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
CDC45 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:6260; DNA replication
GO:6270; DNA replication initiation
GO:727; double-strand break repair via break-induced replication
GO:76; DNA replication checkpoint signaling
GO:6268; DNA unwinding involved in DNA replication
GO:1902977; mitotic DNA replication preinitiation complex assembly
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5813; centrosome
GO:36064; ciliary basal body
GO:71162; CMG complex
GO:31261; DNA replication preinitiation complex
Show all GO termsFunction: GO:5515; protein binding
GO:3682; chromatin binding
GO:3697; single-stranded DNA binding
GO:3688; DNA replication origin binding
Homologs of CDC45 in Model Organisms
- Caenorhabditis elegans
- evl-18
- Danio rerio
- cdc45
- Drosophila melanogaster
- CDC45L
- Mus musculus
- Cdc45
- Rattus norvegicus
- Cdc45
- Saccharomyces cerevisiae
- CDC45
- Schizosaccharomyces pombe
- sna41
In other databases
- CellAge gene expression
- This gene is present as CDC45
External links
- OMIM
- 603465
- Ensembl
- ENSG00000093009
- Entrez Gene
- 8318
- UniGene
- 742418
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CDC45
- GeneCards
- CDC45