Cell Senescence Entries for CDC7
- Cell Types
- Colorectal cancer, Melanoma
- Cell Lines
- A375P, HCT116
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)
CDC7 Gene Information
- HGNC symbol
- CDC7
- Aliases
- CDC7L1; HsCdc7; Hsk1; huCdc7
- Common name
- cell division cycle 7
- Entrez Id
- 8317
- Description
- This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008].
CDC7 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:7165; signal transduction
GO:18105; peptidyl-serine phosphorylation
GO:82; G1/S transition of mitotic cell cycle
GO:727; double-strand break repair via break-induced replication
GO:8284; positive regulation of cell population proliferation
GO:10571; positive regulation of nuclear cell cycle DNA replication
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
And 2 more GO terms Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:45171; intercellular bridge
GO:72686; mitotic spindle
GO:5737; cytoplasm
Show all GO termsFunction: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
Homologs of CDC7 in Model Organisms
- Danio rerio
- cdc7
- Drosophila melanogaster
- CG5790-RA
- Mus musculus
- Cdc7
- Rattus norvegicus
- Cdc7
- Saccharomyces cerevisiae
- CDC7
- Schizosaccharomyces pombe
- hsk1
In other databases
- CellAge gene expression
- This gene is present as CDC7
External links
- OMIM
- 603311
- Ensembl
- ENSG00000097046
- Entrez Gene
- 8317
- UniGene
- 533573
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CDC7
- GeneCards
- CDC7