Cell Senescence Entries for AGT

Cell Types
Vascular smooth muscle
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Kunieda et al. (2006) Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 114(9)953-60 (PubMed)

AGT Gene Information

HGNC symbol
AGT 
Aliases
SERPINA8 
Common name
angiotensinogen 
Entrez Id
183
Description
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019].

AGT Ontologies

Gene Ontology
Process: GO:10951; negative regulation of endopeptidase activity
GO:42310; vasoconstriction
GO:3081; regulation of systemic arterial blood pressure by renin-angiotensin
GO:45893; positive regulation of transcription, DNA-templated
GO:42981; regulation of apoptotic process
GO:61098; positive regulation of protein tyrosine kinase activity
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:7267; cell-cell signaling
GO:50729; positive regulation of inflammatory response
GO:10595; positive regulation of endothelial cell migration
And 80 more GO terms
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5829; cytosol
GO:70062; extracellular exosome
GO:72562; blood microparticle
GO:62023; collagen-containing extracellular matrix
GO:5737; cytoplasm
Function: GO:4867; serine-type endopeptidase inhibitor activity
GO:5515; protein binding
GO:5179; hormone activity
GO:8083; growth factor activity
GO:31702; type 1 angiotensin receptor binding
GO:31703; type 2 angiotensin receptor binding
Show all GO terms

Homologs of AGT in Model Organisms

Danio rerio
agt
Mus musculus
Agt
Rattus norvegicus
Agt

In other databases

LongevityMap
  • This gene is present as AGT

External links

OMIM
106150
Ensembl
ENSG00000135744
Entrez Gene
183
UniGene
19383
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AGT
GeneCards
AGT