Cell Senescence Entries for CDKN2AIP
- Cell Types
- Lung fibroblast
- Cell Lines
- MRC-5, TIG-1
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Hasan et al. (2009) CARF Is a vital dual regulator of cellular senescence and apoptosis. J Biol Chem 284(3)1664-72 (PubMed)
CDKN2AIP Gene Information
- HGNC symbol
- CDKN2AIP
- Aliases
- CARF; FLJ20036
- Common name
- CDKN2A interacting protein
- Entrez Id
- 55602
- Description
- The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
CDKN2AIP Ontologies
- Gene Ontology
-
Process: GO:6974; cellular response to DNA damage stimulus
GO:30307; positive regulation of cell growth
GO:31647; regulation of protein stability
GO:30308; negative regulation of cell growth
GO:9967; positive regulation of signal transduction
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:1652; granular component
Show all GO termsFunction: GO:5515; protein binding
GO:3723; RNA binding
GO:2039; p53 binding
Homologs of CDKN2AIP in Model Organisms
External links
- OMIM
- 615914
- Ensembl
- ENSG00000168564
- Entrez Gene
- 55602
- UniGene
- 644077
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CDKN2AIP
- GeneCards
- CDKN2AIP